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<B>Genetic modifiers of tau levels in neuronal plasma exosomes will be enriched
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   Lead Investigator:    Alan Renton
   Institution      :    Mount Sinai
   E-Mail           :    alan.renton@mssm.edu
   Proposal ID      :    840
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>My central hypothesis is that genetic modifiers of tau levels in neuronal         plasma exosomes will be enriched for genetic loci driving Alzheimer???s disease   outcomes.                                                                         Specific Aims                                                                     1) Identify genetic modifiers of tau levels in neuronal plasma exosomes           a) Identify genetic loci that modify tau levels in neuronal plasma exosomes       b) Determine the effects of APOE genotype and age on tau levels in neuronal       plasma exosomes                                                                   2) Investigate the functional genomics of neuronal plasma exosome tau modifiers   in health and Alzheimer???s disease                                               a) Undertake functional genomic fine mapping of genetic loci that modify tau      levels in neuronal plasma exosomes                                                b) Undertake functional pathway analysis of genetic loci that modify tau levels   in neuronal plasma exosomes                                                       c) Evaluate enrichment between genetic loci that modify tau levels in neuronal    plasma exosomes and genetic loci that influence Alzheimer???s disease outcomes </textarea>